Suddenly stopping your medicine may also worsen your depression. Here are some of the possible effects of quitting too quickly: You get sick. Antidepressant discontinuation syndrome, also called. I have been taking fluoxetine for approximately 1.5 years. I was taking it for Panic disorder, OCD, and Depression. My doctor suddenly decided to take me off this medication without weening me off. I am coming off Prozac also, after over 15 years on it. It has indeed helped me. be level. Indeed, I am also very much experiencing the classic withdraw effects: irritability, agitation ,dizziness, burning ,or tingling sensation ,anxiety confusion ,headache ,insomnia ,tiredness, even panic attacks. As I’m coming off the prozac, I’ve noticed a feeling of depersonalization, but honestly nothing else. I guess what I’m saying is that there is use for prozac and responsible ways to take it and to come off of it. I can not stress enough the change in my life from one year ago to today. I’ve been on and off Prozac since my late 30’s. With periods of being off more than on. I haven’t taken it for about 2 years now and I’m struggling as just coming out of a divorce which has not been easy. Then, follow your doctor's instructions for tapering your Prozac dosage gradually, since it's dangerous to stop taking it suddenly. Be sure to contact your doctor if you experience any unexpected or severe symptoms as you taper off of Prozac. Coming off psychiatric drugs. Explains issues faced when coming off medication, how to approach it, techniques for gradual reduction, possible withdrawal symptoms and how to tell the difference between withdrawal and relapse. And suddenly, you feel like. such as Prozac or Trintellix (vortioxetine). However, longer-acting antidepressants can still sometimes cause discontinuation symptoms. Discontinuation symptoms. Fluoxetine is a prescription antidepressant popularly known by the brand name Prozac. Individuals taking fluoxetine can experience side effects upon abruptly stopping fluoxetine use, a general condition known as antidepressant discontinuation syndrome.